El ABC de los contaminantes emergentes en la salud humana; guía rápida de comprensión en el siglo XXI.
Resumen
Los contaminantes emergentes (CE) son sustancias químicas, sintéticas o biológicas entre las que se encuentran productos farmacéuticos, productos de cuidado personal, hormonas, esteroides, pesticidas, retardantes de flama, surfactantes, aditivos de combustibles, nanomateriales y compuestos industriales. Los CE han llamado la atención en la comunidad científica porque se han detectado en múltiples ambientes, generando preocupación por su potencial peligro para los seres humanos y los ecosistemas, debido a la evidencia de sus efectos tóxicos. La remoción y eliminación de los CE no es fácil comparada con los contaminantes tradicionales y sobre esta esencia se desarrolla el presente trabajo.
Citas
Abdel-Shafy, H.I., Mohamed-Mansour, M.S. (2013). Issue of pharmaceutical compounds in water and wastewater: Sources, impact, and elimination. Egyptian Journal of Chemistry, 5, (5– 6): 449–471. https://doi.org/10.21608/ejchem.2013.1123
Al-Omran, L.S., Harrad, S. (2017). Influence of sampling approach on concentrations of legacy and “novel” brominated flame retardants in indoor dust. Chemosphere, 178, Pages 51-58. https://doi.org/10.1016/j.chemosphere.2017.02.096
Alaee, M., Arias, P., Sjödin, A., Bergman, A. (2003). An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release. Environment International, 29(6):683-9. https://doi.org/10.1016/S0160-4120(03)00121-1
Anchique, Leonardo; Alcázar, Jackson J.; Ramos-Hernandez, Andrea; Méndez-López, Maximiliano; Mora, José R.; Rangel, Norma; Paz, José Luis & Márquez, Edgar (2021). Predicting the Adsorption of Amoxicillin and Ibuprofen on Chitosan and Graphene Oxide Materials: A Density Functional Theory Study. Polymers, 13: 1620. https://doi.org/10.3390/polym13101620
Barro, R., Regueiro, J., Llompart, M., García-Jares, C. (2009). Analysis of industrial contaminants in indoor air: Part 1. Volatile organic compounds, carbonyl compounds, polycyclic aromatic hydrocarbons and polychlorinated biphenyls, Journal of Chromatography A, 1216, Issue 3, Pages 540-566, ISSN 0021-9673, https://doi.org/10.1016/j.chroma.2008.10.117.
Bunke, D., Moritz, S., Brack, W. et al. (2019). Developments in society and implications for emerging pollutants in the aquatic environment. Environmental Sciences Europe, 31, 32. https://doi.org/10.1186/s12302-019-0213-1
Cao J, Zaremba OT, Lei Q, Ploetz E, Wuttke S, Zhu W. (2021). Artificial Bioaugmentation of Biomacromolecules and Living Organisms for Biomedical Applications. ACS Nano, 23;15(3):3900- 3926. https://doi:10.1021/acsnano.0c10144
Castiglioni, S., Zuccato, E., Chiabrando, C., Fanelli, R., & Bagnati, R. (2008). Mass spectrometric analysis of illicit drugs in wastewater and surface water. Mass Spectrometry Reviews, 27(4), 378–394. https://doi.org/10.1002/mas.20168
Chevrier, J., Harley, K.G., Bradman, A., Gharbi, M., Sjödin, A., Eskenazi, B. (2010). Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy. Environmental Health Perspectives, 118(10):1444-9. https://doi:10.1289/ehp.1001905
Clarke, B.O., Smith, S.R. (2011). Review of ‘emerging’ organic contaminants in biosolids and assessment of international research priorities for the agricultural use of biosolids. Environment International, 37(1), 226–247. https://doi.org/10.1016/j.envint.2010.06.004
Colvin, V.L. (2003). The potential environmental impact of engineering nanomaterials. Nature Biotechnology, 21(10), 1166–1170. https://doi.org/10.1038/nbt875
Daughton, C.G. (2013). Pharmaceuticals in the environment: sources and their management. In: Petrovic M, Perez S, Barcelo D, editors. Analysis, removal, effects and risk of pharmaceuticals in the water cycle — occurrence and transformation in the environment. Elsevier; p. 37–69. [chapter 2].
DWI (2007). Drinking Water Inspectorate. Desk based review of current knowledge on pharmaceuticals in drinking water and estimation of potential levels. Final report prepared by Watts and Crane Associates for Drinking Water Inspectorate, Department for Environment, Food and Rural Affairs. https://www.dwi.gov.uk/
El-Kalliny, A.S., Abdel-Wahed, M.S., El-Zahhar, A.A., Hamza, I.A., Gad-Allah, T.A. (2023). Nanomaterials: a review of emerging contaminants with potential health or environmental impact. Discover Nano, 21;18(1):68. https://doi:10.1186/s11671-023-03787-8
European Commission. Pesticides (2009). Food Safety. Pesticides. Disponible en: https://food.ec.europa.eu/plants/pesticides_en
Geissen, V., Mol, H., Klumpp, E., Umlauf, G., Nadal, M., van der Ploeg, M., van de Zee, M. E.A.T.M., Ritsema, C.J. (2015). Emerging pollutants in the environment: A challenge for water resource management, International Soil and Water Conservation Research, Volume 3, Issue 1, Pages 57-65, ISSN 2095-6339. https://doi.org/10.1016/j.iswcr.2015.03.002.
Grand View Research (2025). Market Analysis Report. Pharmaceutical Manufacturing Market Size, Share & Trends Analysis Report By Route of Administration, By Molecule Type, By Drug Development Type, By Sales Channel, By Age Group, By Formulation, By Region, And Segment Forecasts, 2023 – 2030. https://www.grandviewresearch.com/industry-analysis/pharmaceutical-manufacturing-market
Hassan, S.S.M., Abdel-Shafy, H.I., Mansour, M.S.S. (2019). Removal of pharmaceutical compounds from urine via chemical coagulation by green synthesized ZnO-nanoparticles followed by microfiltration for safe reuse, Arabian Journal of Chemistry, 12, Issue 8, Pages 4074-4083. https://doi.org/10.1016/j.arabjc.2016.04.009
Huang, B., Lei, C., Wei, C., Zeng, G. (2014). Chlorinated volatile organic compounds (Cl-VOCs) in environment—sources, potential human health impacts, and current remediation technologies. Environment international, 71, 118-138. https://doi:10.1016/j.envint.2014.06.013
Lapworth, D.J., Baran, N., Stuart, M.E., Ward, R.S. (2012). Emerging organic contaminants in groundwater: A review of sources, fate and occurrence. Environmental Pollution, 163, 287–303. https://doi.org/10.1016/j.envpol.2011.12.034
Liu, B., Zhang, S.G., Chang, C.C. (2020). Emerging pollutants-Part II: Treatment. Water Environment Research, 91(10):1390-1401. https://doi:10.2175/106143013X13698672323308
Loos, R., Locoro, G., Comero, S., Contini, S., Schwesig, D., Werres, F., Balsaa, P., Gans, O., Weiss, S., Blaha, L., Bolchi, M., Gawlik, B.M. (2010). Pan-European survey on the occurrence of selected polar organic persistent pollutants in ground water. Water Research, 44(14):4115-26. https://doi:10.1016/j.watres.2010.05.032.
Matlin, S.A., Cornell, S.E., Krief, A., et al. (2022). Chemistry must respond to the crisis of transgression of planetary boundaries. Chemical Science, 13: 11710–11720.
Meng, L., Gao, S., Zhang, S., Che, X., Jiao, Z., Ren, Y., Wang, C. (2024). Identification of atmospheric emerging contaminants from industrial emissions: A case study of halogenated hydrocarbons emitted by the pharmaceutical industry, Environment International, 192, 109027, ISSN 0160-4120, https://doi.org/10.1016/j.envint.2024.109027
Naidu, R., Biswas, B., Willett, I.R., et al. (2021). Chemical pollution: A growing peril and potential catastrophic risk to humanity. Environment International, 156: 106616.
Nguyen, V. T., Reinhard, M., Karina, G.Y.H. (2011). Occurrence and source characterization of perfluorochemicals in an urban watershed. Chemosphere, 82(9), 1277–1285. https://doi.org/10.1016/j.chemosphere.2010.12.030
Noyes, P.D., Kelly, S.M., Mitchelmore, C.L., Stapleton, H.M. (2010). Characterizing the in vitro hepatic biotransformation of the flame retardant BDE 99 by common carp. Aquatic Toxicology, 15;97(2):142-50. https://doi.org/10.1016/j.aquatox.2009.12.013
Nyagah, M. N., Nyagah, D. M., Njagi, A. (2020). Pharmaceutical Waste: Overview, Management, and Impact of Improper Disposal. Preprints.
O'Flynn, D., Lawler, J., Yusuf, A., Parle-McDermott, A., Harold, D., McCloughlin, T., Holland, L., Regan, F., White, B. (2021). A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic. Analytical Methods, 7;13(5):575-594. https://doi:10.1039/d0ay02098b
OMS. Organización Mundial de la Salud. (2020). Organización de las Naciones Unidas para la Alimentación y la Agricultura. Plaguicidas uso [en línea]. Disponible en https://www.fao.org/faostat/es/#data/RP/visualize
Rahman, F., Langford, K.H., Scrimshaw, M. D., Lester, J.N. (2001). Polybrominated diphenyl ether (PBDE) flame retardants. The Science of the Total Environment, 275(1-3), 1–17. https://doi:10.1016/S0048-9697(01)00852-X PMID:11482396
Rivera-Utrilla, J., Sánchez-Polo, M., Ferro-García, M.Á., Prados-Joya, G., Ocampo-Pérez, R. (2013). Pharmaceuticals as emerging contaminants and their removal from water. A review. Chemosphere, 93(7):1268-87. https://doi.org/10.1016/j.chemosphere.2013.07.059
Rossi, A.S., Fantón, N., Michlig, M.P., Repetti, M.R., Cazenave, J. (2020). Fish inhabiting rice fields: Bioaccumulation, oxidative stress and neurotoxic effects after pesticides application, Ecological Indicators, 113, 106186. https://doi.org/10.1016/j.ecolind.2020.106186
Saleh, T.A. (2020). Trends in the sample preparation and analysis of nanomaterials as environmental contaminants. Trends in Environmental Analytical Chemistry, 28: e00101. https://doi.org/10.1016/j.teac.2020.e00101
Salthammer, T. (2020). Emerging indoor pollutants. International Journal of Hygiene and Environmental Health, 224, 113423. https://doi.org/10.1016/j.ijheh.2019.113423
Schwartz, H., Marushka, L., Chan, H.M., Batal, M., Sadik, T., Ing, A., Fediuk, K., Tikhonov, C. (2021). Pharmaceuticals in source waters of 95 First Nations in Canada. Canadian Journal of Public Health, 112(Suppl 1):133-153. https://doi.org/10.17269/s41997-021-00499-3
Singh, A., Gautam , P.K., Verma, A., Singh, V., Shivapriya, P.M., Shivalkar, S., Sahoo, A.K., Samanta, S.K. (2020). Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review. Biotechnology Reports, 31;25:e00427. https://doi.org/10.1016/j.btre.2020.e00427
Sophia, A.C., Lima, EC. (2018). Removal of emerging contaminants from the environment by adsorption. Ecotoxicology and Environmental Safety, 15;150:1-17. https://doi.org/10.1016/j.ecoenv.2017.12.026
Souza, Reinaldo R.; Gonçalves, Inês M.; Rodrigues, Raquel O.; Minas, Graça; Miranda, J.M.; Moreira, António L.N.; Lima, Rui; Coutinho, Gonçalo; Pereira, J.E.; Moita, Ana S. (2022). Recent advances on the thermal properties and applications of nanofluids: from nanomedicine to renewable energies. Applied Thermal Engineering, 201:117725. https://doi.org/10.1016/j.applthermaleng.2021.117725
Stefanakis, A.I., Becker, J.A. (2020). A Review of Emerging Contaminants in Water: Classification, Sources, and Potential Risks. In I. Management Association (Ed.), Waste Management: Concepts, Methodologies, Tools, and Applications (pp. 177-202). IGI Global Scientific Publishing. https://doi.org/10.4018/978-1-7998-1210-4.ch008
Steffen, W., Richardson, K., Rockström, J., et al. (2015). Planetary boundaries: Guiding human development on a changing planet. Science, 347: 1259855.
Tasca, A.L., Puccini, M., Clematis, D., Panizza, M. (2019). Electrochemical removal of Terbuthylazine:Boron-Doped Diamond anode coupled with solid polymer electrolyte. Environmental Pollution, 251:285-291. https://doi.org/10.1016/j.envpol.2019.04.134
Teodosiu, C., Gilca, A.F., Barjoveanu, G., Fiore, S. (2018). Emerging pollutants removal through advanced drinking water treatment: A review on processes and environmental performances assessment. Journal of Cleaner Production, 197, Part 1, Pages 1210-1221, ISSN 0959-6526, https://doi.org/10.1016/j.jclepro.2018.06.247
Turcios, A.E., Hielscher, M., Duarte, B., Fonseca, V.F., Caçador, I., Papenbrock, J. (2021). Screening of Emerging Pollutants (EPs) in Estuarine Water and Phytoremediation Capacity of Tripolium pannonicum under Controlled Conditions. International Journal of Environmental Research and Public Health, 22;18(3):943. https://doi.org/10.3390/ijerph18030943
USEPA (2010). Environmental Protection Agency. Contaminantes emergentes: nanomateriales. Disponible en: https://19january2021snapshot.epa.gov/sites/static/files/documents/emerging_contaminants_nanomaterials.pdf
USEPA (2025). Environmental Protection Agency. Contaminants of Emerging Concern including Pharmaceuticals and Personal Care Products. Disponible en: https://www.epa.gov/wqc/contaminants-emerging-concern-including-pharmaceuticals-and-personal-care-products
USEPA (2025a). Environmental Protection Agency. Información básica sobre PFAS. Disponible en: https://espanol.epa.gov/espanol/informacion-basica-sobre-pfas
USEPA (2025b). Environmental Protection Agency. What is a Pesticide? [online] Disponible en: https://www.epa.gov/minimum-risk-pesticides/what-pesticide
Vasilachi, I.C., Asiminicesei, D.M., Fertu, D.I., Gavrilescu, M. (2021). Occurrence and Fate of Emerging Pollutants in Water Environment and Options for Their Removal. Water, 13(2), 181. https://doi.org/10.3390/w13020181
Vlachogianni, T., Valavanidis, A. (2014). Nanomaterials: environmental pollution, ecological risks and adverse health effects. Nano Science and Nano Technology An Indian Journal, 8:208–226.
Wang, Fang; Xiang, Leilei; Sze-Yin Leung, Kelvin; …, Wu, Fengchang; Yu, Gang; Tiedje, James M. (2024). Emerging contaminants: A One Health perspective. The Innovation, Volume 5, Issue 4, 100612, ISSN 2666-6758, https://doi.org/10.1016/j.xinn.2024.100612
Wang, Z., Walker, G.W., Muir, D.C.G., et al. (2020). Toward a Global Understanding of Chemical Pollution: A First Comprehensive Analysis of National and Regional Chemical Inventories. Environ. Sci. Technol. 54: 2575–2584.
WHO (2012). World Health Organization. Pharmaceuticals in Drinking Water. https://www.who.int/publications/i/item/9789241502085
Wiesner, M.R., Lowry, G.V., Jones, K.L., Hochella, M.F. Jr, Di Giulio, R.T., Casman, E., Bernhardt, E.S. (2009). Decreasing uncertainties in assessing environmental exposure, risk, and ecological implications of nanomaterials. Environmental Science & Technology, 1;43(17):6458-62. https://doi.org/10.1021/es803621k
Xing, J., Liang, H., Xu, S., Chuah, C.J., Luo, X., Wang, T., Wang, J., Li, G., Snyder, S.A. (2019). Organic matter removal and membrane fouling mitigation during algae-rich surface water treatment by powdered activated carbon adsorption pretreatment: Enhanced by UV and UV/chlorine oxidation. Water Research, 1;159:283-293. https://doi.org/10.1016/j.watres.2019.05.017
Zeng, Q., Li, M., Xie, S.H., Gu, L J., Yue, J., Cao, W.C., Zheng, D., Liu, A.L., Li, Y.F., Lu, W.Q. (2013). Baseline blood trihalomethanes, semen parameters and serum total testosterone: a cross-sectional study in China. Environment international, 54, 134-140. https://doi.org/10.1016/j.envint.2013.01.016
Zhang, Peng; Tan, Xiaofei; Liu, Yunguo; Zeng, Guangming; Yin, Zhihong; Ye, Shujing; Zeng, Zhiwei (2019). Microwave-assisted chemical modification method for surface regulation of biochar and its application for estrogen removal. Process Safety and Environment Protection 128: 329–341. https://doi.org/10.1016/j.psep.2019.06.009
Zhang, Y., Geißen, S.U., Gal, C. (2008). Carbamazepine and diclofenac: Removal in wastewater treatment plants and occurrence in water bodies. Chemosphere, 73(8), 1151–1161. https://doi.org/10.1016/j.chemosphere.2008.07.086
Zhen, Guangyin; Pan, Yang; Lu, Xueqin; Li, Yu-You; Zhang, Zhongyi; Niu, Chengxin; Kumar, Gopalakrishnan; Kobayashi, Takuro; Zhao, Youcai; Xu, Kaiqin (2019). Anaerobic membrane bioreactor towards biowaste biorefinery and chemical energy harvest: Recent progress, membrane fouling and future perspectives. Renewable Sustainable Energy Reviews, 115: 109392. https://doi.org/10.1016/j.rser.2019.109392








