Influencia de los factores de riesgo en la finalización del embarazo en el primer trimestre de gestación en relación con la edad materna.

Deysi Viviana Bonilla Ledesma; Cintya Alejandra Pomasqui Pomasqui; Julio Jesús Vargas Peña

doi:10.46377/dilemas.v11i1.3841

Deysi Viviana Bonilla Ledesma Universidad Regional Autónoma de Los Andes
Cintya Alejandra Pomasqui Pomasqui Universidad Regional Autónoma de Los Andes
Julio Jesús Vargas Peña Universidad Regional Autónoma de Los Andes

DOI: https://doi.org/10.46377/dilemas.v11i1.3841

Palabras clave: factores de riesgo, factores genéticos, abortos, aneuploidías, anomalías cromosómicas

Resumen

El objetivo de este estudio es realizar una revisión exhaustiva de la literatura científica, basada en ensayos clínicos aleatorios prospectivos, estudios de cohortes, casos y revisiones publicadas en importantes bases de datos como PubMed, Scielo y Google Académico. Se busca identificar y analizar los factores de riesgo que influyen en la terminación del embarazo en casos de aborto espontáneo. Entre los factores de riesgo identificados, se destaca la influencia de factores genéticos y cromosómicos como la causa más común de abortos espontáneos. Las anomalías cromosómicas fetales, como la incapacidad de los cromosomas para separarse correctamente (trisomía y monosomía), representan una proporción significativa de los casos. La edad materna se ha identificado como el principal factor de riesgo de aneuploidías.

Citas

Antoniotti, G. S., Coughlan, M., Salamonsen, L. A., & Evans, J. (2018). Obesity associated advanced glycation end products within the human uterine cavity adversely impact endometrial function and embryo implantation competence. Human Reproduction, 33(4), 654-665.

Baudler, A., Schmidt, I., Langner, M., Greiner, A., & Schröder, U. (2015). Does it have to be carbon? Metal anodes in microbial fuel cells and related bioelectrochemical systems. Energy & Environmental Science, 8(7), 2048-2055.

Benn, P., Malvestiti, F., Grimi, B., Maggi, F., Simoni, G., & Grati, F. R. (2019). Rare autosomal trisomies: comparison of detection through cell‐free DNA analysis and direct chromosome preparation of chorionic villus samples. Ultrasound in Obstetrics & Gynecology, 54(4), 458-467.

Biggio Jr, J. R., Chapman, V., Neely, C., Cliver, S. P., & Rouse, D. J. (2010). Fetal anomalies in obese women: the contribution of diabetes. Obstetrics and gynecology, 115(2 0 1), 290.

Boots, C., & Stephenson, M. D. (2011). Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review. In Seminars in reproductive medicine 29(06), 507-513.

Borole, A. P., Hamilton, C. Y., Vishnivetskaya, T. A., Leak, D., Andras, C., Morrell-Falvey, J., ... & Davison, B. (2009). Integrating engineering design improvements with exoelectrogen enrichment process to increase power output from microbial fuel cells. Journal of Power Sources, 191(2), 520-527.

Dimitriadis, E., Menkhorst, E., Saito, S., Kutteh, W. H., & Brosens, J. J. (2020). Recurrent pregnancy loss. Nat ure reviews disease primers, 6(1), 98.

Friedler, S., Margalioth, E. J., Kafka, I., & Yaffe, H. (1993). Incidence of post-abortion intra-uterine adhesions evaluated by hysteroscopy—a prospective study. Human Reproduction, 8(3), 442-444.

Ghimire, P. R., Akombi-Inyang, B. J., Tannous, C., & Agho, K. E. (2020). Association between obesity and miscarriage among women of reproductive age in Nepal. PLoS One, 15(8), e0236435.

Helgstrand, S., & Andersen, A. M. N. (2005). Maternal underweight and the risk of spontaneous abortion. Acta obstetricia et gynecologica Scandinavica, 84(12), 1197-1201.

Kaser, D. (2018). The status of genetic screening in recurrent pregnancy loss. Obstetrics and Gynecology Clinics, 45(1), 143-154.

Khanal, V., Adhikari, M., Sauer, K., & Zhao, Y. (2013). Factors associated with the introduction of prelacteal feeds in Nepal: findings from the Nepal demographic and health survey 2011. International breastfeeding journal, 8(1), 1-9.

Kirk, S. F., Penney, T. L., & McHugh, T. L. (2010). Characterizing the obesogenic environment: the state of the evidence with directions for future research. Obesity reviews, 11(2), 109-117.

Laisk, T., Soares, A. L. G., Ferreira, T., Painter, J. N., Laber, S., Bacelis, J., ... & Lindgren, C. M. (2019). The genetic architecture of sporadic and recurrent miscarriage. bioRxiv, 575167.

Lashen, H., Fear, K., & Sturdee, D. W. (2004). Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case–control study. Human reproduction, 19(7), 1644-1646.

Lathi, R. B., Hazard, F. K. G., Heerema-McKenney, A., Taylor, J., & Chueh, J. T. (2011). First trimester miscarriage evaluation. In Seminars in reproductive medicine. 29(06), 463-469.

Negrato, C. A., Mattar, R., & Gomes, M. B. (2012). Adverse pregnancy outcomes in women with diabetes. Diabetology & metabolic syndrome, 4(1), 1-6.

Popescu, F., Jaslow, C. R., & Kutteh, W. H. (2018). Recurrent pregnancy loss evaluation combined with 24-chromosome microarray of miscarriage tissue provides a probable or definite cause of pregnancy loss in over 90% of patients. Human Reproduction, 33(4), 579-587.

Rich-Edwards, J. W., Spiegelman, D., Garland, M., Hertzmark, E., Hunter, D. J., Colditz, G. A., ... & Manson, J. E. (2002). Physical activity, body mass index, and ovulatory disorder infertility. Epidemiology, 184-190.

Robinson, G. E. (2014). Pregnancy loss. Best practice & research Clinical obstetrics & gynaecology, 28(1), 169-178.

Rodríguez Blanco, C. L., De los Ríos Palomino, M., González Rodríguez, A. M., Quintana Blanco, D. S., & Sánchez Reyes, I. (2020). Estudio sobre aspectos epidemiológicos que influyen en el aborto espontáneo. Multimed, 24(6), 1349-1365.

Strand, E. A. (2015). Increasing the management options for early pregnancy loss: the economics of miscarriage. American Journal of Obstetrics & Gynecology, 212(2), 125-126.

Tang, S., Huang, J., Lin, J., & Kuang, Y. (2021). Adverse effects of pre-pregnancy maternal underweight on pregnancy and perinatal outcomes in a freeze-all policy. BMC Pregnancy and Childbirth, 21(1), 1-9.

Tennant, P. W. G., Rankin, J., & Bell, R. (2011). Maternal body mass index and the risk of fetal and infant death: a cohort study from the North of England. Human reproduction, 26(6).

van Dijk, M. M., Kolte, A. M., Limpens, J., Kirk, E., Quenby, S., van Wely, M., & Goddijn, M. (2020). Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis. Human reproduction update, 26(3), 356-367.

von Feigenblatt, O. F. (2022). SVNS-based multicriteria methods for the selection of management elements for academic diplomacy. Neutrosophic Sets and Systems, 52, 241-250.