Efficacy of Direct Oral Anticoagulants (DOAC) in antithrombotic therapy for patients with non-valvular atrial fibrillation.

Abstract

The objective of this study is to analyze the characteristics of direct oral anticoagulants (DOACs) and determine which of them is the most appropriate according to the clinical characteristics of each patient. For this, an exhaustive search was carried out in MEDLINE through the PUBMED database, using terms such as "DOACs", "treatment of AF with DOACs", "antithrombotic treatment of atrial fibrillation", "direct oral anticoagulants", "dabigatran", "rivaroxaban" and "apixaban". The results obtained revealed that DOACs reduce the bleeding rate in patients requiring anticoagulation, and apixaban showed the lowest rate of bleeding and cardiovascular complications. In conclusion, a rigorous analysis is required to determine the most appropriate DOAC in each case.